The first three patients with melanoma have completed dosing in the IMCgp100 phase I trial in the UK. Enrolment is now open for the second cohort in which patients will be given a higher dose, as planned. This is the first milestone in a dose-finding study in patients with advanced malignant melanoma, designed to establish a tolerability of increasing doses of IMCgp100 When this arm of the study is complete, a second phase is planned to assess the effect of the selected dose on pharmacodynamic markers when given repeatedly to a larger group of patients.