Sami Malkit; Rizkallah Pierre J; Dunn Steve; Molloy Peter; Moysey Ruth; Vuidepot Annelise; Baston Emma; Todorov Penio; Li Yi; Gao Feng; Boulter Jonathan M; Jakobsen Bent K. Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry. Protein engineering, design & selection : PEDS 2007;20(8):397-403.

Purbhoo Marco A; Li Yi; Sutton Deborah H; Brewer Joanna E; Gostick Emma; Bossi Giovanna; Laugel Bruno; Moysey Ruth; Baston Emma; Liddy Nathaniel; Cameron Brian; Bennett Alan D; Ashfield Rebecca; Milicic Anita; Price David A; Classon Brendan J; Sewell Andrew K; Jakobsen Bent K. The HLA A*0201-restricted hTERT(540-548) peptide is not detected on tumor cells by a CTL clone or a high-affinity T-cell receptor. Molecular cancer therapeutics 2007;6(7):2081-91.

Ashfield Rebecca; Jakobsen Bent K. Making high-affinity T-cell receptors: a new class of targeted therapeutics. IDrugs : the investigational drugs journal  2006;9(8):554-9.

Purbhoo Marco A; Sutton Deborah H; Brewer Joanna E; Mullings Rebecca E; Hill Maxine E; Mahon Tara M; Karbach Julia; Jäger Elke; Cameron Brian J; Lissin Nikolai; Vyas Paresh; Chen Ji-Li; Cerundolo Vincenzo; Jakobsen Bent K
Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors. Journal of immunology (Baltimore, Md. : 1950)  2006;176(12):7308-16.

Dunn Steven M; Rizkallah Pierre J; Baston Emma; Mahon Tara; Cameron Brian; Moysey Ruth; Gao Feng; Sami Malkit; Boulter Jonathan; Li Yi; Jakobsen Bent K. Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. Protein science : a publication of the Protein Society 2006;15(4):710-21.

Boulter J M; Jakobsen B K. Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens. Clinical and experimental immunology 2005;142(3):454-60.

Molloy Peter E; Sewell Andrew K; Jakobsen Bent K. Soluble T cell receptors: novel immunotherapies. Current opinion in pharmacology 2005;5(4):438-43.

Li Yi; Moysey Ruth; Molloy Peter E; Vuidepot Anne-Lise; Mahon Tara; Baston Emma; Dunn Steven; Liddy Nathaniel; Jacob Jansen; Jakobsen Bent K; Boulter Jonathan M. Directed evolution of human T-cell receptors with picomolar affinities by phage display. Nature biotechnology 2005;23(3):349-54.

Boulter Jonathan M; Glick Meir; Todorov Penio T; Baston Emma; Sami Malkit; Rizkallah Pierre; Jakobsen Bent K. Stable, soluble T-cell receptor molecules for crystallization and therapeutics. Protein engineering 2003;16(9):707-11.

Further Reading

Cole David K; Pumphrey Nicholas J; Boulter Jonathan M; Sami Malkit; Bell John I; Gostick Emma; Price David A; Gao George F; Sewell Andrew K; Jakobsen Bent K. Human TCR-binding affinity is governed by MHC class restriction.  Journal of immunology (Baltimore, Md. : 1950) 2007;178(9):5727-34.

Liddy Nathaniel; Molloy Peter E; Bennett Alan D; Boulter Jonathan M; Jakobsen Bent K; Li Yi. Production of a soluble disulfide bond-linked TCR in the cytoplasm of Escherichia coli trxB gor mutants. Molecular biotechnology 2010;45(2):140-9.

Cole David K; Yuan Fang; Rizkallah Pierre J; Miles John J; Gostick Emma; Price David A; Gao George F; Jakobsen Bent K; Sewell Andrew K. Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor. The Journal of biological chemistry 2009;284(40):27281-9.

Cole David K; Dunn Steven M; Sami Malkit; Boulter Jonathan M; Jakobsen Bent K; Sewell Andrew K. T cell receptor engagement of peptide-major histocompatibility complex class I does not modify CD8 binding. Molecular immunology  2008;45(9):2700-9.

Yuan Fang; Georgiou Theonie; Hillon Theresa; Gostick Emma; Price David A; Sewell Andrew K; Moysey Ruth; Gavarret Jessie; Vuidepot Annelise; Sami Malkit; Bell John I; Gao George F; Rizkallah Pierre J; Jakobsen Bent K. Crystallization and preliminary X-ray structural studies of a Melan-A pMHC-TCR complex.Acta crystallographica. Section F, Structural biology and crystallization communications  2007;63(Pt 9):758-60.

Cole David K; Rizkallah Pierre J; Gao Feng; Watson Neil I; Boulter Jonathan M; Bell John I; Sami Malkit; Gao George F; Jakobsen Bent K. Crystal structure of HLA-A*2402 complexed with a telomerase peptide. European journal of immunology 2006;36(1):170-9.

Laugel Bruno; Boulter Jonathan M; Lissin Nikolai; Vuidepot Annelise; Li Yi; Gostick Emma; Crotty Laura E; Douek Daniel C; Hemelaar Joris; Price David A; Jakobsen Bent K; Sewell Andrew K. Design of soluble recombinant T cell receptors for antigen targeting and T cell inhibition. The Journal of biological chemistry 2005;280(3):1882-92.