Senior Scientist (Infectious Disease)
91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK
Senior Scientist (Infectious Disease)
Immunocore is a late-stage biotechnology company pioneering the development of a novel class of TCR bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infection and autoimmune disease. We are developing a deep pipeline in multiple therapeutic areas, including five clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical programs.
It is an exciting time to join Immunocore. Our most advanced oncology therapeutic candidate, tebentafusp, has demonstrated an overall survival benefit in a randomized Phase 3 clinical trial in metastatic uveal melanoma, a cancer that has historically proven to be insensitive to other immunotherapies. The company also recently completed its Initial Public Offering and was listed on the NASDAQ.
- Devise and lead the generation ID-relevant in vitro models, including co-culture systems and organoid cultures, together with appropriate pathogen-specific read-outs, to evaluate on-target activity of ImmTAX molecules, proactively seeking internal or external input where needed
- Recommend, provide rationale and drive studies to probe the biology of immune cell-pathogen interactions that are pertinent to project priorities and company goals.
- Lead high risk / high reward collaborations with experts in academia / industry to advance or complement in-house disease-relevant models and build proof of concept for ImmTAX in ID indications
- Contribute to preclinical cell biology package (pharmacology / toxicology) for ImmTAX candidates; provide data package and study interpretation in a defined area, at the standard required to support regulatory filing.
- Proactively seek to expand scientific knowledge of ID indications that may be amenable to treatment, cure or diagnosis using Immunocore’s technology
- Design tools to assess unconventional ImmTAVs for ID indications
- Contribute to cross-departmental initiatives to accelerate advancement of ImmTAX molecules, including exploring opportunities at the interface between ID and Oncology or Autoimmune Disease; lead an area of investigation by drawing on expertise in other teams and assembling a project team if needed
- Source and acquire infectious primary tissue and viral isolates following HTA and H&S policies
- Contribute to project decision making and support the selection of lead candidates
- Contribute to or lead the development of manuscripts for publication and external presentations
- Depending on projects allocated, work at containment level 3 laboratory (CL3) may be required. Post-holder would be required to follow and guide new risk assessments, maintain CL3 competency, attend CL3 users’ meetings or approval of minutes and maintain CL3 training records. Anticipate / identify new risks and update relevant policies, in collaboration with CL3 manager, to ensure safety & understanding of users
EXPERIENCE AND KNOWLEDGE
- Knowledge of infectious diseases biology, including virology
- Expertise in cell and molecular biology (qPCR, cloning, T cell cloning, flow cytometry, functional experiments, primary cell cultures).
- Evidence of scientific contribution to ID disease biology in the form of scientific publications and conference presentations
- Tissue disaggregation, explant or organoid cultures experience.
- Experience in next-gen sequencing
EDUCATION & QUALIFICATIONS
- Essential: PhD in cell biology, virology, immunology, or related discipline.
- Alternatively, a B.S. or M.S. with significant work experience in relevant scientific areas and a record of scientific accomplishment (e.g., project progression, published manuscripts and/or abstracts).
- Essential: Relevant industrial or post-doctoral academic experience