Scientist - Display Technologies
Immunocore is a late-stage biotechnology company pioneering the development of a novel class of TCR bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infection and autoimmune disease. We are developing a deep pipeline in multiple therapeutic areas, including five clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical programs.
It is an exciting time to join Immunocore. Our most advanced oncology therapeutic candidate, tebentafusp, has demonstrated an overall survival benefit in a randomized Phase 3 clinical trial in metastatic uveal melanoma, a cancer that has historically proven to be insensitive to other immunotherapies. The company also recently completed its Initial Public Offering and was listed on the NASDAQ.
MAIN PURPOSE OF JOB
To conduct and design experimental investigations, in association with the team and with appropriate guidance from colleagues and managers, enabling the advancement of the Company pipeline, process, or technology capabilities.
• Conducting experiments, observing, interpreting and responding to results.
• Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses.
• Maintaining accurate records of all work by completing laboratory notebooks on time, following Company procedures
• Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff.
• Operating in accordance with the Company’s Health and Safety policies, especially within a laboratory environment.
• Experiments: independently conducting experiments based on established protocols. Understanding the limitations and expected outcomes of an experiment; seeking guidance and support from colleagues and line managers when the outcomes are not as expected or the approaches may need to be reconsidered.
• Priorities: planning and working to agreed experiment deadlines, schedules and objectives; advising managers and colleagues of risks and deviations.
• Technical Knowledge: proactively seeking to expand scientific knowledge through individual learning, peer to peer mentoring, and line managerial support. Demonstrating this through practising and sharing acquired skills with colleagues.
• Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Proactively seeking guidance on policy if required.
• Laboratory equipment: undergoing training on the use of technical instruments; using equipment appropriately.
• Health & Safety: complies with all H&S requirements, attending appropriate training courses.
• Reporting: communicating and presenting research findings at meetings with colleagues.
KEY RESPONSIBILITIES – ROLE SPECIFIC
Display technologies scientist specific responsibilities include some or all of listed below:
• Support development and maintenance of novel TCR phage libraries for TCR discovery and further enhance our phage display technology.
• Present data in relevant PTMs for process enhancement.
• Support development of a mammalian display platform to drive more efficient TCR generation and selection.
• Work on generation of T Cell activation reporter tools to enhance selection of more potent TCRs.
• Develop and optimise cellular tools for mammalian display of TCRs and scHLA.
• Develop negative selection strategies for TCR identification and affinity maturation.
• Optimise TCR discovery and affinity enhancement process to make it more efficient and productive as well as reducing the timelines.
• Reporting experimental results to the broader team and teams within Research
EXPERIENCE AND KNOWLEDGE
• Worked in a bench-based laboratory environment with competence in key techniques relevant to the department
• Competent in the safe use of general laboratory equipment
• Ability to independently analyse and trouble-shoot the technical aspects of these core techniques
• Showing a strong analytical mind with the ability to interpret complex datasets and propose sound experimental strategies
• Worked and contributed actively in a diverse team environment
• Presented results and scientific practices
• Excellent communication and organisational skills
• Recorded results in a concise and timely way, and in compliance with agreed standards
• Knowledge of Immunology
• Able to meaningfully contribute on occasion to scientific team discussions, in particular with regards to the interpretation of their own data
EXPERIENCE AND KNOWLEDGE – ROLE SPECIFIC
Display technologies scientist specific experience and knowledge include some or all of listed below
• Experience in generating TCR discovery and affinity maturation libraries.
• Experience in molecular biology including DNA cloning, PCR, and sequencing.
• Experience in screening protein display libraries and analysing output data.
• Experience in protein production, purification and characterisation.
• Experience in genome engineering and generating bespoke cellular tools for mammalian display.
• Experience in cell biology with a good knowledge of T cell biology.
• Experience in flow cytometry.
• Experience in generating TCR or scHLA CHO display libraries and selection analysis.
• Experience in maintaining and generating different mammalian cell lines for experimental use.
KEY BEHAVIOURAL ATTRIBUTES – ALL STAFF
• Openness and honesty
Readily offering information pertaining to work in hand whether positive or negative.
• Taking responsibility
Being prepared to accept full responsibility for tasks entrusted to them; seeing tasks through to completion and dealing with the consequences of failure or success.
Being flexible to new ideas and approaches; changes of plans, objectives and/or priorities. Handling disjointed tasks effectively.
• Team spirit
Being able to work productively with others to achieve tasks. Showing consideration for the needs and feelings of others.
SPECIFIC BEHAVIOURAL ATTRIBUTES
• Analytical Thinking - Tackling problems by using a logical and sequential approaches, making systematic comparisons of two or more alternatives.
• Attention to Communication - Writing and speaking concisely and appropriately, tailoring the content and the experience of the audience by using a range of tools, methods and approaches.
• Diagnostic Information Gathering - Seeking perspectives, information and clarification on problems from others, checking multiple sources for complete and accurate information.
• Managing Self Performance - Proactively seeking feedback from others and responding to this appropriately. Taking full responsibility for own performance and also the performance of others formally or informally.
• Results Orientated - Setting challenging but obtainable goals for self and others, ensuring efforts are focused on meeting or exceeding these, and that they shared clearly and used to measure success.
• Teamwork - Working cooperatively as part of a team, actively listening and constructively responding to others ideas.
• Thoroughness - Ensuring own as well as others work and information is complete and accurate, setting up procedures to ensure a high quality of work and to monitor ongoing projects
• Written and oral communication - Writing and speaking clearly to share thoughts and information concisely and appropriately.
• Building collaborative relationships - Developing, maintaining and strengthening partnerships with others who can provide information, assistance and support.
• Fostering teamwork - Working cooperatively with others listening, responding and offering support for ideas and proposals, whilst constructively expressing differing views.
• Influencing others - Presenting arguments that address others concerns and issues, gaining support for these using own expertise and other experts to help shape opinions.
• Initiative - Proactively identifying what needs to be done, undertaking more than what might be normally required and independently taking action to change the direction of events.
• Interpersonal awareness - Understanding, interpreting and anticipating the concerns and feelings of others, responding attentively and putting measures in place to address these sensitively.
• Conceptual thinking - Adopting a holistic, abstract or theoretical perspective in order to notice similarities between different and apparently unrelated situations.
• Developing others - Coaching and supporting others to develop their capabilities, providing appropriate and specific feedback.
• Forward thinking - Anticipating the implications and consequences of situations, taking appropriate action in order to be prepared for possible contingencies and planning accordingly.
• Fostering innovation - Developing, proposing and supporting new approaches, methods and technologies that improve effectiveness, working cooperatively with others to produce and implement these innovative solutions.
• Managing change - Supporting, implementing and initiating innovation and organizational changes to improve effectiveness, helping others to successfully manage these changes.
• Providing motivational support - Encouraging others, sharing ideas in a way that energizes groups, acknowledging people for their contributions and promptly tackling any problems impacting morale.
(Please see the intranet for further information on behaviours, those in Italic are new to this role/ different to the previous level)
EDUCATION & QUALIFICATIONS
• Essential: BSc. Or MSc. in protein engineering, biochemistry, molecular biology or related discipline
• Desirable: PhD in related discipline
• Desirable: Relevant industrial or post-doctoral academic experience