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Senior Scientist, Bioanalytical, Immunology

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Senior Scientist, Translational Medicine Bioanalytical


Immunocore is a late-stage biotechnology company pioneering the development of a novel class of TCR bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infection and autoimmune disease. We are developing a deep pipeline in multiple therapeutic areas, including five clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical programs.

It is an exciting time to join Immunocore. Our most advanced oncology therapeutic candidate, tebentafusp, has demonstrated an overall survival benefit in a randomized Phase 3 clinical trial in metastatic uveal melanoma, a cancer that has historically proven to be insensitive to other immunotherapies. The company also recently completed its Initial Public Offering and was listed on the NASDAQ.

Key responsibilities

  • Design and build custom LBA and cell-based pharmacokinetic, immunogenicity and biomarker assays suitable for detection of target analytes in biological matrices.
  • Lead technical transfer of validation-ready assays to suitable third-party laboratory vendors, and oversee method validation studies according to regulatory guidance and industry best practices
  • Monitor CRO assay performance and sample analysis; review and summarize PK and ADA results
  • Participate in clinical study teams as bioanalytical representative to coordinate sample collection, analysis and reporting according to established timelines
  • Drive exploratory bioanalytical projects; interpret data and make recommendations for next steps/future directions
  • Design and characterize custom reagents, controls and biological matrices for use in bioanalytical assays; effectively manage inventory of applicable study samples, reagents and controls
  • Communicate project results internally via department/project meetings and seminars and externally in relevant conferences.
  • Operate in accordance with the company‚Äôs health and safety policies.

Experience and Knowledge

  • Strong Immunology background
  • Advanced knowledge of bioanalytical assays for protein macromolecules with strong scientific and technical skills in method development and validation
  • A minimum of 5 years of hands-on experience in the development and validation of quantitative immunoassays and immunogenicity assays for biologics (e.g. antibodies, proteins or peptides)
  • Experience in aseptic cell culture and cell-based assay development
  • Familiar with current regulatory guidance and industry best practices for development and validation of bioanalytical methods for large molecule biologics
  • Experience in GLP and/or clinical regulatory compliance
  • Strong analytical skills, and a demonstrated ability to work both independently and in a team setting
  • Excellent verbal and written communication skills

Education and qualifications

  • BSc/MSc with 6-8 years or PhD with 3-5 years of relevant professional experience in immunology, biochemistry or related discipline

 

Lead with Science and Discover What is Within:

  • We Value Entrepreneurship and Diversity
  • Respect, Trust, and Integrity
  • Competitive compensation
  • Private medical and dental benefits.
  • 25 days Annual Leave and Bank Holidays
  • 4x Salary Life Insurance
  • 5% Pension Match
  • Income Protection
  • Parental Leave

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