MAIN PURPOSE OF JOB
To conduct and design experimental investigations enabling the advancement of the Company pipeline, process, or technology capabilities, proposing improvements for consideration by colleagues and managers.
KEY RESPONSIBILITIES – ALL SCIENTISTS
- Conducting experiments, observing, interpreting and responding to results.
- Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses.
- Maintaining accurate records of all work by completing laboratory notebooks on time, following Company procedures
- Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff.
- Operating in accordance with the Company’s Health and Safety policies, especially within a laboratory environment.
- Experiments: independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
- Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
- Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department both internally and externally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge. Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the Company.
- Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
- Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment.
- Health & Safety: championing and helping others to understand H&S within the company, providing ad-hoc training as required.
- Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.
KEY RESPONSIBILITIES – ROLE SPECIFIC
- Perform immunological assays such as ELISpot/ELISA, killing assays and FACS using multiple cell types.
- On-board a range of cell assays appropriate to the functional effector being assessed and provide guidance and input to research and pre-clinical scientists.
- Design and implementation of high-throughput screening assays for potency and specificity assessment.
- Transfer of stablished screening assays to automated platforms.
- Manage/maintain multiple cell lines.
- Generate concise reports on-the-fly as data is generated and adapt assays to return most information-rich data.
- Assimilate multiparameter data and disseminate data in an efficient way.
- Able to meaningfully contribute to scientific team discussions, in particular with regards to the interpretation of data.
EXPERIENCE AND KNOWLEDGE
- Worked in a bench-based laboratory environment with a recognized and established expertise key techniques relevant to the department
- Competent in the safe use of general laboratory equipment
- Ability to independently analyse and trouble-shoot the technical aspects of these core techniques
- Showing a strong analytical mind with the ability to interpret complex datasets and propose sound experimental strategies
- Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
- Driven the direction and progress of work to aid attainment of deadlines or results
- Presented detailed scientific findings or papers to internal and external audiences
- Ability to network between teams and disciplines
- Recorded results in a concise and timely way, and in compliance with agreed standards
- Mentored and coached less experienced colleagues in scientific practices and theory
- Acted as key point of contact, assuming responsibility for at least one piece of equipment
- Knowledge of Immunology and experience of performing immunological assays
- Industry experience
- Presented posters at external conferences
- Led a project small team, formally or informally, through a change in practice including project management
- Proven publication record
- Kept abreast of current scientific writing and concepts
EXPERIENCE AND KNOWLEDGE – ROLE SPECIFIC
- Experienced in cell-based assay development and assay miniaturisation.
- Experienced in automation and use of liquid handling robots (e.g. Hamilton robotic platform or similar) to increase functional assay efficiency.
- Previous experience working with T cells/lymphocyte assays.
- Adept at co-ordinating assay management across functions.
- Previous experience in screening biotherapeutics (e.g. antibodies, bi-/multi-specifics) beneficial.
- Experienced in assay transfer to automated platforms
- Experienced in High Content Imaging technologies
- Experienced in molecular biological techniques/cloning
- Generation of cell lines using diverse methods (for e.g. DNA-transfection, lentivirus transduction, CRISPR etc.).
KEY BEHAVIOURAL ATTRIBUTES – ALL STAFF
- Openness and honesty
Readily offering information pertaining to work in hand whether positive or negative.
- Taking responsibility
Being prepared to accept full responsibility for tasks entrusted to them; seeing tasks through to completion and dealing with the consequences of failure or success.
Being flexible to new ideas and approaches; changes of plans, objectives and/or priorities. Handling disjointed tasks effectively.
- Team spirit
Being able to work productively with others to achieve tasks. Showing consideration for the needs and feelings of others.
SPECIFIC BEHAVIOURAL ATTRIBUTES
· Analytical Thinking - Tackling problems by using a logical and sequential approaches, making systematic comparisons of two or more alternatives.
· Attention to Communication - Writing and speaking concisely and appropriately, tailoring the content and the experience of the audience by using a range of tools, methods and approaches.
· Diagnostic Information Gathering - Seeking perspectives, information and clarification on problems from others, checking multiple sources for complete and accurate information.
· Managing Self Performance - Proactively seeking feedback from others and responding to this appropriately. Taking full responsibility for own performance and also the performance of others formally or informally.
· Results Orientated - Setting challenging but obtainable goals for self and others, ensuring efforts are focused on meeting or exceeding these, and that they shared clearly and used to measure success.
· Teamwork - Working cooperatively as part of a team, actively listening and constructively responding to others ideas.
· Thoroughness - Ensuring own as well as others work and information is complete and accurate, setting up procedures to ensure a high quality of work and to monitor ongoing projects
· Written and oral communication - Writing and speaking clearly to share thoughts and information concisely and appropriately.
· Building collaborative relationships - Developing, maintaining and strengthening partnerships with others who can provide information, assistance and support.
· Fostering teamwork - Working cooperatively with others listening, responding and offering support for ideas and proposals, whilst constructively expressing differing views.
· Influencing others - Presenting arguments that address others concerns and issues, gaining support for these using own expertise and other experts to help shape opinions.
· Initiative - Proactively identifying what needs to be done, undertaking more than what might be normally required and independently taking action to change the direction of events.
· Interpersonal awareness - Understanding, interpreting and anticipating the concerns and feelings of others, responding attentively and putting measures in place to address these sensitively.
· Conceptual thinking - Adopting a holistic, abstract or theoretical perspective in order to notice similarities between different and apparently unrelated situations.
· Developing others - Coaching and supporting others to develop their capabilities, providing appropriate and specific feedback.
· Forward thinking - Anticipating the implications and consequences of situations, taking appropriate action in order to be prepared for possible contingencies and planning accordingly.
· Fostering innovation - Developing, proposing and supporting new approaches, methods and technologies that improve effectiveness, working cooperatively with others to produce and implement these innovative solutions.
· Managing change - Supporting, implementing and initiating innovation and organizational changes to improve effectiveness, helping others to successfully manage these changes.
· Providing motivational support - Encouraging others, sharing ideas in a way that energizes groups, acknowledging people for their contributions and promptly tackling any problems impacting morale.
(Please see the intranet for further information on behaviours, those in Italic are new to this role/ different to the previous level)
EDUCATION & QUALIFICATIONS
- Essential: BSc. Or MSc. in protein engineering, biochemistry, molecular biology or related discipline
- Desirable: PhD in related discipline
- Desirable: Relevant industrial or post-doctoral academic experience