Job description

Scientist, Immunohistochemistry (Translational Medicine)

Abingdon, UK

Scientist, Immunohistochemistry (Translational Medicine)

Abington, UK

Immunocore is an innovative and dynamic biotechnology company leading the development of a novel platform of T cell receptor-based therapeutics for the treatments of cancer, infectious and autoimmune diseases.

Immunocore has a well- established pipeline of wholly owned programmes, of world leading science and strong IP position, which has led to discovery collaborations with Genentech, GlaxoSmithKline, Medimmune as well as a co-discovery & co-development partnership with Lilly, and recent investment from the Bill & Melinda Gates Foundation.

We are now seeking a Scientist to conduct and design experimental investigations using Immunohistochemistry and/or Immunofluorescence to analyse clinical trial and non-clinical samples, alongside supporting diagnostic activities.

 

 Key responsibilities

  • Performing Immunohistochemical or IF (single/multiplex) analysis on patient samples from clinical trials using previously established assays. Antibody specificity testing and setting up new GCP-compliant IHC protocols for patient sample analysis.
  • Perform experimental investigation of target expression/frequency and exploring candidate biomarkers in non-clinical disease tissue, using IHC/IF, RNA ISH, and/or molecular biology techniques such as RT-qPCR and next-generation sequencing.
  • Support diagnostics activities with histological, IHC and molecular techniques, such as antibody specificity testing, protocol optimisation and validation. Identification of sample sets for assay validation by CRO.
  • Digital histology image capture analysis, following previously established protocols, or protocol development with support.
  • Performing experimental procedures, equipment maintenance and keeping experimental and maintenance records in accordance with HTA and /or GCP standards, as relevant.
  • Analysis and preparation of experimental results for presentation within matrix project teams.

 

EXPERIENCE AND KNOWLEDGE

  • Background in histopathology, cell biology and/or immunology.
  • Experience in histology and immunohistochemistry techniques.
  • Worked in a bench-based molecular biology laboratory environment.
  • Experience with diagnostics assay development for patient selection in clinical trials.
  • Recorded results in a concise and timely way, helping shape the agreed standards and approach.
  • Learnt about new practices based through observation, self-learning and an enquiring mind.
  • Worked and contributed actively in a diverse team environment.

Desirable

  • Experience with immuno-pathology.
  • Significant experience of RNA in situ hybridization and/or multiplex IHC/IF.
  • Experience analysing clinical trial samples with IHC or IF based biomarkers.
  • Experience with qRT-PCR assay development and validation.
  • Experience with digital image analysis.
  • Experience in a GCP- and/or HTA-regulated environment.
  • Presented results and scientific practices to internal teams.
  • Mentored and coached colleagues in scientific practices and theory.

 

EDUCATION & QUALIFICATIONS

  • Essential: BSc. Or MSc. in Biological Sciences, Oncology, Immunology or other related discipline
  • Desirable: PhD in related discipline

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