Job description

Scientist - Characterisation

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Scientist - Characterisation

Immunocore is a late-stage biotechnology company pioneering the development of a novel class of TCR bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infection and autoimmune disease. We are developing a deep pipeline in multiple therapeutic areas, including five clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical programs.

It is an exciting time to join Immunocore. Our most advanced oncology therapeutic candidate, tebentafusp, has demonstrated an overall survival benefit in a randomized Phase 3 clinical trial in metastatic uveal melanoma, a cancer that has historically proven to be insensitive to other immunotherapies. The company also recently completed its Initial Public Offering and was listed on the NASDAQ.


The main purpose of the role is the characterisation of our products and processes with a focus on mass spectrometry (LC-MS).


  • Writing study protocols and reports.
  • Developing characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis methods.
  • Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
  • Supporting drug substance and drug product impurity characterisation and identification
  • Performing protein sequence and post translational modification identification, including glycosylation analysis.
  • Performing host cell protein identification and quantitation of drug product and process intermediates.
  • Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
  • Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment.

Experience and Knowledge:

  • Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of proteins.
  • Worked in a bench-based biopharmaceutical laboratory environment or as a post doc in a relevant field
  • Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
  • Presented detailed scientific findings and papers to internal and external audiences
  • Mentored and coached less experienced colleagues in scientific practices and theory
  • Established as an expert amongst peers in one or more of the following areas:
    • electrophoretic
    • chromatographic
    • mass spectrometry

Education and Qualifications:

  • You will need a degree in Life Sciences or related discipline.
  • PhD or MSc in chemistry, Biochemistry or relevant scientific area.
  • Relevant postgraduate experience (2+ years) working in an industrial or academic setting.



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