Job description

Scientist - Characterisation

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Scientist - Characterisation

Immunocore is a late-stage biotechnology company pioneering the development of a novel class of TCR bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infection and autoimmune disease. We are developing a deep pipeline in multiple therapeutic areas, including five clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical programs.

It is an exciting time to join Immunocore. Our most advanced oncology therapeutic candidate, tebentafusp, has demonstrated an overall survival benefit in a randomized Phase 3 clinical trial in metastatic uveal melanoma, a cancer that has historically proven to be insensitive to other immunotherapies. The company also recently completed its Initial Public Offering and was listed on the NASDAQ.

Role:

The main purpose of the role is the characterisation of our products and processes with a focus on mass spectrometry (LC-MS).

Responsibilities

  • Writing study protocols and reports.
  • Developing characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis methods.
  • Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
  • Supporting drug substance and drug product impurity characterisation and identification
  • Performing protein sequence and post translational modification identification, including glycosylation analysis.
  • Performing host cell protein identification and quantitation of drug product and process intermediates.
  • Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
  • Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment.

Experience and Knowledge:

  • Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of proteins.
  • Worked in a bench-based biopharmaceutical laboratory environment or as a post doc in a relevant field
  • Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
  • Presented detailed scientific findings and papers to internal and external audiences
  • Mentored and coached less experienced colleagues in scientific practices and theory
  • Established as an expert amongst peers in one or more of the following areas:
    • electrophoretic
    • chromatographic
    • mass spectrometry

Education and Qualifications:

  • You will need a degree in Life Sciences or related discipline.
  • PhD or MSc in chemistry, Biochemistry or relevant scientific area.
  • Relevant postgraduate experience (2+ years) working in an industrial or academic setting.

 

 

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