Job description

Target Identification and Validation Senior Scientist, Disease Biology

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

TARGET IDENTIFICATION AND VALIDATION SENIOR SCIENTIST, DISEASE BIOLOGY 

Join a pioneering biotech with a collegial atmosphere and a passion for harnessing every individual’s unique set of skills in our fight against disease.

At Immunocore, we have a vision to transform the way we understand and treat the most challenging medical conditions of our time, including cancer, autoimmune disorders and infection. In January 2022, in the U.S., we launched the world’s first T-cell receptor therapy, built on a novel technology designed to overcome the limitations of our natural immune systems.

Joining us at the most exciting time in our history, you will be part of a team that values trust and innovation, and that cherishes different ways of thinking.

The Role:

We are looking for a dedicated, enthusiastic, independent and collaborative Senior Scientist with in-depth understanding of cancer biology/immunology and mechanisms underlying cancer progression into an aggressive and difficult-to-treat disease.

With a very high level of expertise in FACS cell sorting, Flow cytometry, histology and molecular biology, you will contribute to discovery and validation of novel cancer targets for ImmTAC immunotherapy.

Responsibilities:

  • Analyse relevant literature to help triaging a list of potential cancer targets by gaining in-depth understanding of the target biological role and cancer disease biology
  • Establish/develop new methods for the in-house single cell analysis and become a go-to person for FACS cell sorting, Flow cytometry and single-cell RNAseq
  • Analyse expression of the most promising cancer/autoimmune targets on mRNA and protein level and determine their suitability for ImmTAX targeting
  • Enhance our target identification and validation processes by providing innovative suggestions
  • Collaborate cross-functionally to develop optimal cancer disease models for ImmTAC testing
  • Analyse and report experimental results verbally and in writing

Experience and Knowledge:

  • Flow cytometry and cell sorting, primer design and qPCR, immunohistochemistry, FFPE/cryo tissue sectioning, cell culture
  • Highly desirable skills include: single-cell RNA sequencing, bioinformatics

Education and Qualifications:

  • PhD in Cancer Biology, Cancer Immunology or Autoimmunity
  • Relevant industrial or postdoctoral academic experience (> 3 years)
  • Excellent oral and written communication skills
  • Demonstrated record of scientific accomplishment as evidenced by publications, presentations, patent applications, and/or contributions to regulatory submissions

Lead with Science and Discover What is Within:

  • We Value Entrepreneurship and Diversity
  • Respect, Trust, and Integrity
  • Competitive compensation
  • Private medical and dental benefits.
  • 25 days Annual Leave and Bank Holidays
  • 4x Salary Life Insurance
  • 5% Pension Match
  • Income Protection
  • Parental Leave

 

 

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