Job description

Senior Scientist-Characterisation

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Immunocore is a late-stage biotechnology company pioneering the development of a novel class of TCR bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infection and autoimmune disease. We are developing a deep pipeline in multiple therapeutic areas, including five clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical programs.

It is an exciting time to join Immunocore. Our most advanced oncology therapeutic candidate, tebentafusp, has demonstrated an overall survival benefit in a randomized Phase 3 clinical trial in metastatic uveal melanoma, a cancer that has historically proven to be insensitive to other immunotherapies. The company also recently completed its Initial Public Offering and was listed on the NASDAQ.

Role:

The main purpose of the role is the characterisation of our products and processes with a focus on mass spectrometry (LC-MS).

Responsibilities:

  • Developing characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis methods.
  • Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
  • Supporting drug substance and drug product process development by performing characterisation of process intermediates.
  • Performing host cell protein identification and quantitation of drug product and process intermediates.
  • Writing study protocols and reports.
  • Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department both internally and externally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge. Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the Company works; sharing these with leaders across the Company.
  • Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
  • Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment.
  • Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.

Experience and Knowledge:

  • Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of proteins.
  • Worked in a bench-based biopharmaceutical laboratory environment or as a post doc in a relevant field
  • Established as an expert amongst peers in one or more of the following areas:
    • electrophoretic
    • chromatographic
    • mass spectrometry
  • Worked and contributed actively in a diverse team environment
  • Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
  • Presented detailed scientific findings and papers to internal and external audiences

Education and Qualifications:

  • You will need a degree in Life Sciences or related discipline.
  • PhD or MSc in chemistry, Biochemistry or relevant scientific area.
  • Relevant postgraduate experience (2+ years) working in an industrial or academic setting.

 

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