Job description

Senior Scientist- Discovery Research

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Senior Scientist- Discovery Research

Join a pioneering biotech with a collegial atmosphere and a passion for harnessing every individual’s unique set of skills in our fight against disease.

At Immunocore, we have a vision to transform the way we understand and treat the most challenging medical conditions of our time, including cancer, autoimmune disorders and infection. In January 2022, in the U.S., we launched the world’s first T-cell receptor therapy, built on a novel technology designed to overcome the limitations of our natural immune systems.

Joining us at the most exciting time in our history, you will be part of a team that values trust and innovation, and that cherishes different ways of thinking.

 

The role

The Discovery Research Department is seeking a Senior Scientist to join one of the T-cell receptor (TCR) discovery teams. As part of the team, you will contribute to the development and improvement of Immunocore’s TCR identification and validation work of novel oncology targets. The candidate will design and conduct experimental investigations, in association with the team and with appropriate guidance from colleagues and managers, enabling the advancement of the company technology capabilities.

Key Responsibilities:

Perform experimental work to contribute to:

  • Culture and expansion of T cells from healthy donors and patients
  • Screening of T cell lines/clones against novel oncology targets
  • Cloning of T cells against novel oncology targets
  • Analysis of TCR usage and validation of peptide targets
  • Development of TCR-transduced reporter systems for validation of TCR mediated specific reactivity to selected targets 
  • Conducting experiments, observing, interpreting, and responding to results that will support research activities company-wide
  • Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses.
  • Generate concise reports on-the-fly as data is generated and adapt assays to return most information-rich data.
  • Assimilate multiparameter data and disseminate data in an efficient way.
  • Able to meaningfully contribute to scientific team discussions, with regards to the interpretation of data.

Experience and Knowledge:

  • Experience in cell biology and T cell immunology, including purification and culture of primary T cells, T cell cloning, general cell culture, phenotypic analysis, Flow cytometry, functional experiments (ELISA, ELISPOT, killing assays) - multiple is desirable
  • Operated in a bench-based laboratory environment with competence in key techniques relevant to the department
  • Recorded results in a concise and timely way, and in compliance with agreed standards
  • Worked and contributed actively in a diverse team environment
  • Presented results and scientific practices
  • Excellent communication and organisational skills
  • Attention to detail

Education and Qualifications:

  • BSc. or MSc. in immunology, biochemistry, cellular biology or related discipline 
  • PhD in related discipline 
  • Relevant industrial or post-doctoral academic experience 

Benefits:

  • We Value Entrepreneurship and Diversity
  • Respect, Trust, and Integrity
  • Competitive compensation
  • Private medical and dental benefits.
  • 25 days Annual Leave and Bank Holidays
  • 4x Salary Life Insurance
  • 5% Pension Match
  • Income Protection
  • Parental Leave

 

 

 

 

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