Job description

Senior Scientist (Autoimmune Disease Biology)

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Senior Scientist (Autoimmune Disease Biology)

Join a pioneering biotech with a collegial atmosphere and a passion for harnessing every individual’s unique set of skills in our fight against disease.

At Immunocore, we have a vision to transform the way we understand and treat the most challenging medical conditions of our time, including cancer, autoimmune disorders and infection. In January 2022, in the U.S., we launched the world’s first T-cell receptor therapy, built on a novel technology designed to overcome the limitations of our natural immune systems.

Joining us at the most exciting time in our history, you will be part of a team that values trust and innovation, and that cherishes different ways of thinking.


The role

We are looking for an enthusiastic and collaborative Senior Scientist to join our Autoimmune Disease Biology team. Based on our world leading TCR technology platform we are discovering and advancing novel targeted therapeutic agents for the treatment of Autoimmunity and Inflammation (ImmTAAIs).

This is a very exciting time to join the team as we’re pushing novel “first in class” approaches towards the clinic to help patients! It’s an opportunity for a passionate and creative team player who is keen to learn, innovate, collaborate and contribute to successes of a high-performance team within a pioneering, clinical-stage biotechnology company. The candidate should have a PhD in Immunology or Cellular Immunology, with at least 2 years of relevant postdoctoral academic or industrial experience. A strong background in T cell biology and/or autoimmune immunology is a key requirement, together with a proven track record of scientific accomplishments. Knowledge of Treg biology and previous work experience in a high profile autoimmune/inflammation research group would be a distinct advantage.


  • Independently design, conduct and interpret cellular screening assays and studies to probe the biology of Tregs in the context of autoimmunity.
  • Contribute to the autoimmune biology platform by characterising the impact of targeted immune modulators on Tregs and other immune cells, participating in the generation of disease-relevant models using cell lines and primary cells.
  • Interpret and communicate data at internal and external meetings,
  • Actively participate in team and project meetings, supporting the Autoimmune team by providing innovative ideas and suggestions
  • Stay abreast of relevant literature, have in-depth understanding of the pathophysiology of Autoimmune diseases and contribute to scientific strategy of the Autoimmune team,




  • Ability to design and run cell-based assays / functional assays to address key scientific questions.
  • Proficiency in isolation of various immune cells (e.g. CD8+, CD4+ T cells, Tregs), maintenance of cell lines and primary cell culture.
  • Experience in immunology techniques such as ELISA, Flow Cytometry, T cell proliferation, cytokine analysis and reporter assay technologies.
  • High attention to detail, good time management and excellent communication skills.
  • Strong team player with the ability to work independently.
  • Ability to mentor more junior scientists and assist with the planning/supervision of their lab work.

Highly desirable:

  • Expertise in Treg biology and proficiency in experimental techniques to characterize their impact on inflammation/autoimmunity.

Lead with Science and Discover What is Within:

  • We Value Entrepreneurship and Diversity
  • Respect, Trust, and Integrity
  • Competitive compensation
  • Private medical and dental benefits.
  • 25 days Annual Leave and Bank Holidays
  • 4x Salary Life Insurance
  • 5% Pension Match
  • Income Protection
  • Parental Leave


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