Job description

Scientist - Protein Science Pipeline

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Scientist - Protein Science Pipeline 

Join a pioneering biotech with a collegial atmosphere and a passion for harnessing every individual’s unique set of skills in our fight against disease.

At Immunocore, we have a vision to transform the way we understand and treat the most challenging medical conditions of our time, including cancer, autoimmune disorders and infection. In January 2022, in the U.S., we launched the world’s first T-cell receptor therapy, built on a novel technology designed to overcome the limitations of our natural immune systems.

Joining us at the most exciting time in our history, you will be part of a team that values trust and innovation, and that cherishes different ways of thinking.

 

The role

The Research department is now seeking a collaborative and enthusiastic Scientist, with a passion for learning, to join the Infectious Diseases Protein Science Pipeline team. As a part of the team you will be responsible for the engineering of ImmTAX molecules in the pipeline from the initial identification and characterization of wild type TCRs through to the production of affinity enhanced, potent and specific molecules. 

Key responsibilities

  • Design and independently conduct experimental investigations, with guidance from line manager or colleagues where appropriate
  • Designing and producing DNA constructs for TCR and ImmTAX expression and DNA libraries for affinity maturation
  • TCR and ImmTAX expression in bacterial and mammalian cells and purification via affinity tags or using ion-exchange and size exclusion chromatography (AKTA system)
  • Analysing TCR and ImmTAX binding affinity, kinetics and specificity using SPR (BIAcore) method
  • Identifying specific TCRs from TCR-phage libraries through series of selection rounds
  • Perform TCR affinity maturation using phage display to identify high affinity and specific molecules
  • Independently analyse and report experimental results and present at company meetings
  • Work collaboratively with other groups and functional areas to advance the project
  • Maintain accurate records of all work by following Company procedures

Experience and knowledge

  • Several years experience in a number of the following areas:
    • Protein expression in bacterial and/or mammalian systems
    • Protein purification using column chromatography methods and AKTA system (such as via affinity tags, ion exchange and size exclusion)
    • Analysis of protein-protein interactions using SPR (BIAcore)
    • Molecular cloning of DNA constructs (primer design, PCR and gel electrophoresis)
    • Construction of DNA libraries and screening using display technologies
  • High attention to detail, excellent time management and communication skills
  • Ability to work independently and actively contribute in a diverse, collaborative team environment

Education and qualification

  • PhD or BSc/MSc. with several years relevant experience in biochemistry, protein engineering, molecular biology or related discipline

Lead with Science and Discover What is Within:

  • We Value Entrepreneurship, Diversity, Respect, Trust, and Integrity
  • Competitive compensation
  • Private medical and dental benefits.
  • 25 days Annual Leave and Bank Holidays
  • 4x Salary Life Insurance
  • 5% Pension Match
  • Income Protection
  • Parental Leave

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