Job description

Scientist (Immunohistochemistry)

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK


Join a pioneering biotech with a collegial atmosphere and a passion for harnessing every individual’s unique set of skills in our fight against disease.

At Immunocore, we have a vision to transform the way we understand and treat the most challenging medical conditions of our time, including cancer, autoimmune disorders and infection. In January 2022, in the U.S., we launched the world’s first T-cell receptor therapy, built on a novel technology designed to overcome the limitations of our natural immune systems.

Joining us at the most exciting time in our history, you will be part of a team that values trust and innovation, and that cherishes different ways of thinking.

The Role:

We are now seeking a Scientist to conduct and design experimental investigations using histology and immunohistochemistry techniques to analyse clinical trial samples to aid in understanding further the mechanism of action of our molecules. This role will also involve supporting diagnostic activities.


  • Performing Immunohistochemical or IF (single/multiplex) analysis on patient samples from clinical trials using established assays.
  • Support diagnostics activities with histological, IHC and molecular techniques, such as antibody specificity testing, protocol optimisation and validation.
  • Digital histology image capture analysis, following previously established protocols, or protocol development with support.
  • Perform experimental investigation of target expression using IHC/IF, RNA ISH, and molecular biology techniques.
  • Performing experimental procedures, equipment maintenance and keeping experimental and maintenance records in accordance with HTA and /or GCP standards, as relevant.
  • Analysis and preparation of experimental results for presentation within matrix project teams.


  • Background in histopathology and/or immunology.
  • Experience in histology and immunohistochemistry techniques.
  • Experience with digital image analysis.
  • Recorded results in a concise and timely way, helping shape the agreed standards and approach.
  • Learnt about new practices based through observation, self-learning and an enquiring mind.
  • Worked and contributed actively in a diverse team environment.
  • Excellent communication, organizational skills and attention to detail.


  • Experience with immuno-pathology.
  • Experience with diagnostics assay development for patient selection in clinical trials.
  • Significant experience of RNA in situ hybridization and/or multiplex IHC/IF.
  • Experience analysing clinical trial samples with IHC or IF based biomarkers.
  • Experience in a GCP- and/or HTA-regulated environment.
  • Presented results and scientific practices to internal teams.
  • Mentored and coached colleagues in scientific practices and theory.


  • Essential: BSc. Or MSc. in Biological Sciences, Oncology, Immunology or other related discipline.
  • Desirable: PhD in related discipline.

Lead with Science and Discover What is Within:

  • We Value Entrepreneurship and Diversity
  • Respect, Trust, and Integrity
  • Competitive compensation
  • Private medical and dental benefits.
  • 25 days Annual Leave and Bank Holidays
  • 4x Salary Life Insurance
  • 5% Pension Match
  • Income Protection
  • Parental Leave


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