Job description

Scientist - Bioanalytical

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Scientist - Bioanalytical

Join a pioneering biotech with a collegial atmosphere and a passion for harnessing every individual’s unique set of skills in our fight against disease.

At Immunocore, we have a vision to transform the way we understand and treat the most challenging medical conditions of our time, including cancer, autoimmune disorders and infection. In January 2022, in the U.S., we launched the world’s first T-cell receptor therapy, built on a novel technology designed to overcome the limitations of our natural immune systems.

Joining us at the most exciting time in our history, you will be part of a team that values trust and innovation, and that cherishes different ways of thinking.

The Role:.

To design, develop and validate fit-for-purpose custom pharmacokinetic and immunogenicity assays used in ImmTAC clinical programs and conduct experiments to characterize patient PK, PD and ADA responses.


  • Design and build custom LBA and/or cell-based pharmacokinetic and immunogenicity assays suitable for use in stage appropriate clinical studies..
  • Lead technical transfer of validation-ready assays to suitable third-party laboratory vendors, and oversee method validation studies according to regulatory guidance and industry best practices.
  • Monitor CRO assay performance and sample analysis; review and summarize PK and ADA results.
  • Participate in clinical study teams as bioanalytical representative to coordinate sample collection, analysis and reporting according to established timelines.
  • Design and execute exploratory bioanalytical projects; interpret data and make recommendations for next steps/future directions.
  • Design and characterize custom reagents, controls and biological matrices for use in bioanalytical assays; effectively manage inventory of applicable study samples, reagents and controls.
  • Keep abreast of technical advances in relevant fields through self-study and attending training sessions and conferences.
  • Communicate results internally in lab meetings and seminars and externally in relevant conferences.
  • Operate in accordance with the company’s health and safety policies.


  • BSc/MSc with 5-7 years or PhD with 2-3 years of relevant professional experience in immunology, biochemistry or related discipline.
  • Working knowledge and understanding of bioanalytical assays for protein macromolecules with strong scientific and technical skills in method development and validation.
  • A minimum of 3 years of hands-on experience in the development and validation of quantitative immunoassays and immunogenicity assays for biologics (e.g. antibodies, proteins or peptides).
  • Experience in aseptic cell culture and cell-based assay development.
  • Familiar with current regulatory guidance and industry best practices for development and validation of bioanalytical methods for large molecule biologics.
  • Strong analytical experience on technical platforms such as MSD, ELISA and cell based assays.
  • Experience in GLP and/or clinical regulatory compliance.
  • Strong analytical skills, and a demonstrated ability to work both independently and in a team setting.
  • Excellent verbal and written communication skills.

Lead with Science and Discover What is Within:

  • We Value Entrepreneurship and Diversity
  • Respect, Trust, and Integrity
  • Competitive compensation
  • Private medical and dental benefits.
  • 25 days Annual Leave and Bank Holidays
  • 4x Salary Life Insurance
  • 5% Pension Match
  • Income Protection
  • Parental Leave


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