Job description

Associate Scientist, Analytical Development & Validation

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

Associate Scientist-Assay Development and Validation

The main purpose of the role is to develop methods for the chromatography, electrophoresis and immunoassay based analysis of TCR based biotherapeutics to support stability, lot release and comparability testing as part of product development.

RESPONSIBILITIES

  • Scientific: 
    • Running pre-established experimental investigations, with guidance from line managers, a mentor or colleagues.
    • Developing and qualifying high/ultra high performance liquid chromatography (HPLC/UHPLC), gel / capillary electrophoresis and immunoassay methods that support stability, lot release and comparability testing as part of biopharmaceutical product development.
    • Supporting process development by testing process intermediates and performing investigations.
    • Contributing to the writing of operating procedures and study reports.
  • Priorities: working to agreed experimental priorities and deadlines; raising issues or concerns with managers or colleagues so that these can be addressed.
  • Technical knowledge: actively developing own knowledge, drawing on the experience of others and self-learning.
  • Laboratory records: Ensuring that all records and data are up to date, on time and recorded to the correct standard, checking with a mentor or colleagues if unsure.
  • Laboratory equipment: attending training on the use of technical instruments, using equipment appropriately, correctly and tidily.
  • Health & Safety: compliance with all H&S requirements, attending appropriate training programmes.

 

EXPERIENCE AND KNOWLEDGE

Essential

  • A background in recombinant protein or antibody/biopharmaceutical analytical development or QC, with 1 or more years’ experience gained in industry.
  • Hands on expertise of HPLC/UHPLC (e.g. size exclusion, ion exchange, reverse phase, hydrophobic interaction) for analysis of proteins.
  • Hands on expertise of electrophoretic (e.g. SDS PAGE) or ELISA methods for analysis of proteins.
  • Recorded results and information in a concise, accurate and timely way
  • Learned about new practices through observation, self-learning and an enquiring mind
  • Worked and contributed actively in a diverse team environment.

 

Desirable

  • Experience of capillary electrophoresis (CE SDS), gel based IEF, imaging capillary IEF, Western blotting
  • Knowledge of GMP
  • Experience of lab organisation/maintenance
  • Proactive in ensuring high quality of their work and seeking additional responsibilities to help meeting the goals of the team
  • Familiar with principles of assay qualification/ validation i.e. robustness and suitability

 

You will need a BSc. or MSc. in biochemistry, molecular biology or related discipline.

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