Associate Scientist - Analytical Development Process Support and Reagents

Immunocore, UK

Immunocore is an innovative and dynamic biotechnology company developing a unique platform of T Cell antigen receptor-based therapeutics, called ImmTAXs, as a novel class of treatments for cancer, infectious and autoimmune diseases.

Immunocore has a well- established pipeline of wholly owned programmes, of world leading science and strong IP position, which has led to discovery collaborations with Genentech, GlaxoSmithKline, Astra Zeneca as well as a co-discovery & co-development partnership with Lilly, and recent investment from the Bill & Melinda Gates Foundation.

The main purpose of the role is to provide analytical support for process development and characterisation of the company’s assets.

RESPONSIBILITIES

• Supporting process development by testing process intermediates and performing investigations.
• Performing analytical method development and qualification experiments for ImmTAX process analysis, and process related impurity testing, with guidance from others
• Conducting experiments, observing, interpreting and responding to results.
• Priorities: working to agreed experimental priorities and deadlines; raising issues or concerns with managers or colleagues so that these can be addressed.
• Technical knowledge: actively developing own knowledge, drawing on the experience of others and self-learning.
• Laboratory records: Ensuring that all records and data are up to date, on time and recorded to the correct standard, checking with a mentor or colleagues if unsure.
• Laboratory equipment: attending training on the use of technical instruments, using equipment appropriately, correctly and tidily.
• Health & Safety: compliance with all H&S requirements, attending appropriate training programmes.

EXPERIENCE AND KNOWLEDGE

Essential

• Hands on expertise of SDS PAGE, ELISA assays and aseptic technique.
• Generation of buffers and reagents following operational procedures
• Performing routine laboratory procedures i.e. pH, conductivity and spectrometry
• Recorded results and information in a concise, accurate and timely way
• Learned about new practices through observation, self-learning and an enquiring mind
• Worked and contributed actively in a diverse team environment.

Desirable

• A background in recombinant protein or antibody/biopharmaceutical analytical development or QC, with 1 or more years’ experience gained in industry.
• Experience of capillary electrophoresis (CE SDS), gel based IEF, imaging capillary IEF (cIEF), Western blotting, HPLC
• Some impurity testing experience (one or more of Host cell protein ELISA, Host cell DNA, Endotoxin, process residuals)
• Knowledge of GMP
• Experience of lab organisation/maintenance
• Proactive in ensuring high quality of their work and seeking additional responsibilities to help meeting the goals of the team
• Familiar with principles of assay qualification/ validation

You will need a BSc. or MSc. in biochemistry, molecular biology or related discipline.