Accelerating the time from bench to bedside





Middleton M.R.

Tebentafusp, A TCR/Anti-CD3 Bispecific Fusion Protein Targeting gp100, Potentially Activated Antitumour Immune Responses in Patients with Metastatic Melanoma

Fergusson J.R.

Epub ahead of print: Immune-mobilising monoclonal T cell receptors mediate specific and rapid elimination of Hepatitis B-infected cells

Coles C.H., Mulvaney R.M.

T cell receptors with distinct specificity profiles use different binding modes to engage an identical peptide-HLA complex. J Immunol. 2020 Apr 1;204(7):1943-1953.

Damato B.E.

Tebentafusp: T Cell Redirection for the Treatment of Advanced Uveal Melanoma. Cancers 2019 Jul 11;11(7). pii: E971.

Madura F.

TCR-induced alteration of primary MHC peptide anchor residue. Eur. J. Immunol. 2019 Jul;49(7):1052-1066.

Lowe K.L.

Novel TCR-based biologics: mobilising T cells to warm ‘cold’ tumours. Cancer Treat Rev. 2019 Jul;77:35-43.

Dobrzycki T., Ciuntu A.

Assessing the potency of T cell redirecting therapeutics using in vitro cancer cell killing assays. Immuno-Oncology: Cellular and Translational Approaches, Springer Methods. 2019

Sato T, et al.

Intra-patient escalation dosing strategy with IMCgp100 results in mitigation of T cell based toxicity and preliminary efficacy in advanced uveal melanoma (2017) ASCO.

Carvajal, R, et al.

Safety, efficacy and biology of the gp100 TCR-based bispecific T cell redirector, IMCgp100 in advanced uveal melanoma in two Phase 1 trials (2017) SITC.

Boudousquie C. et al.

Polyfunctional response by ImmTAC (IMCgp100) redirected CD8+ and CD4+ T cells (2017) Immunology. 152(3):425-438.

Middleton, R M.

Safety, pharmacokinetics and efficacy of IMCgp100, a first-in-class soluble TCR-antiCD3 bispecific T cell redirector with solid tumour activity: Results from the FIH study in melanoma (2016) ASCO.

Bossi G. et al.

ImmTAC-redirected tumour cell killing induces and potentiates antigen cross-presentation by dendritic cells. (2014) Cancer Immunol Immunother. 63(5):437-48.

Bossi G. et al.

Examining the presentation of tumor-associated antigens on peptide-pulsed T2 cells. (2013) Oncoimmunology. Nov 1;2(11):e26840.

Oates J. et al.

ImmTACs for targeted cancer therapy: Why, what, how, and which (2015) Mol Immunol. 67(2 Pt A):67-74.

McCormack E. et al.

Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors. (2013) Cancer Immunol Immunother 62(4):773-85.

Oates J. and Jakobsen B.K.

ImmTACs: Novel bi-specific agents for targeted cancer therapy. (2013) Oncoimmunology 2(2):1-2.

Liddy N. et al.

Monoclonal TCR-redirected tumor cell killing. (2012) Nat Med 18(6):980-7.

Yang H. et al.

Elimination of latently HIV-infected cells from antiretroviral therapy-suppressed subjects by engineered immune mobilising T cell receptors. (2016) Molecular Therapy. 24(11):1913-1925.

Liddy N. et al.

Production of a soluble disulfide bond-linked TCR in the cytoplasm of Escherichia coli trxB gor mutants. (2010) Mol Biotechnol 45(2):140-9.

Dunn S.M. et al.

Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity. (2006) Protein Sci 15(4):710-21.

Li Y. et al.

Directed evolution of human T-cell receptors with picomolar affinities by phage display. (2005) Nat Biotechnol 23(3):349-54.

Ashfield R. and Jakobsen B.K.

Making high-affinity T-cell receptors: a new class of targeted therapeutics. (2006) IDrugs 9(8):554-9.

Boulter J.M. and Jakobsen B.K.

Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens. (2005) Clin Exp Immunol 142(3):454-60.

Boulter J.M. et al.

Stable, soluble T-cell receptor molecules for crystallization and therapeutics. (2003) Protein Eng 16(9):707-11.

Sami M. et al.

Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry. (2007) Protein Eng Des Sel 20(8):397-403.

Raman, M. C. et al.

Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy. (2016) Sci Rep 6. 18851.

Cameron B.J. et al.

Identification of a Titin-derived HLA-A1-presented peptide as a cross-reactive target for engineered MAGE A3-directed T cells. (2013) Sci Trans Med Aug 7;5(197):197ra103.

Hickman, E. S. et al.

Antigen Selection for Enhanced Affinity T-Cell Receptor-Based Cancer Therapies. (2016) J Biomol Screen. 21(8):769-85.

Purbhoo M.A. et al.

Quantifying and imaging NY-ESO-1/LAGE-1-derived epitopes on tumor cells using high affinity T cell receptors. (2006) J Immunol 176(12):7308-16.

Lissin N. et al.

High-Affinity Monoclonal T-cell receptor (mTCR) Fusions. Fusion Protein Technologies for Biopharmaceuticals: Applications and Challenges. (2013).

Hassan N.J. and Oates J.

The T Cell Promise. (2013) European Biopharmaceutical Review (Summer 2013).

Aleksic M. et al.

Different affinity windows for virus and cancer-specific T-cell receptors: implications for therapeutic strategies. (2012) Eur J Immunol 42(12):3174-9.

Sato T, et al.

Redirected T cell lysis in patients with metastatic uveal melanoma with gp100-direct TCR IMCgp100: Overall survival findings (2018) ASCO.

Patel M et al.

iS-CellR: a user-friendly tool for analyzing and visualizing single-cell RNA sequencing data (2018). Bioinformatics.

Harper J, et al.

An approved in vitro approach to preclinical safety and efficacy evaluation of engineered T cell receptor anti-CD3 bispecific (ImmTAC) molecules (2018). PLOS One.