Job description

Scientist (Translational Medicine)

Abingdon, UK

Scientist, Translational Medicine Lab

Immunocore, UK

Immunocore is a late-stage biotechnology company pioneering the development of a novel class of TCR bispecific immunotherapies designed to treat a broad range of diseases, including cancer, infection and autoimmune disease. We are developing a deep pipeline in multiple therapeutic areas, including five clinical stage programs in oncology and infectious disease, advanced pre-clinical programs in autoimmune disease and multiple earlier pre-clinical programs.

It is an exciting time to join Immunocore. Our most advanced oncology therapeutic candidate, tebentafusp, has demonstrated an overall survival benefit in a randomized Phase 3 clinical trial in metastatic uveal melanoma, a cancer that has historically proven to be insensitive to other immunotherapies. The company also recently completed its Initial Public Offering and was listed on the NASDAQ.

We are now seeking an enthusiastic Scientist to join the Translational Medicine Lab team. The main purpose of the role is to design and conduct experiments using patient samples from clinical trials in order to generate predictive hypotheses and further our understanding of the mechanism of action of our therapeutics.    

Key responsibilities

  • Design and perform multi-colour flow cytometry analysis of patient samples from our clinical trials.
  • Perform biomarker analysis of serum samples from clinical trials.
  • Perform experimental procedures, equipment maintenance and keeping experimental and maintenance records in accordance with HTA and /or GCP standards, as relevant.
  • Communicate results internally in lab meetings and seminars and externally in relevant conferences.
  • Keep abreast of technical advances in relevant fields through self-study and attending training sessions and conferences.

Experience and Knowledge

Essential:

  • Experience in multi-colour flow cytometry and immunophenotyping.
  • Competency in performing and analysing immunoassays such as ELISA or multiplex assays (eg MSD and Luminex).
  • Aseptic cell culture techniques.
  • Excellent oral and written communication skills.
  • The ability to work both independently and as part of a team.

Desirable:

  • Experience with processing and analysing clinical trial samples.
  • Knowledge of T cell Immunology / cancer biology.
  • Experience in application of GCP / HTA principles.

Education and qualifications

  • Essential: BSc Or MSc in Immunology or Cancer Biology or related discipline.
  • Desirable: PhD in related discipline with relevant industrial or postdoctoral experience.

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