Job description

Senior Scientist – New Technology and Assay Development Group/Protein Science Research

91 Park Drive, Milton Park, Oxfordshire, OX14 4RY, UK

SENIOR SCIENTIST- NEW ASSAY DEVELOPMENT GROUP/ PROTEIN SCEINCE RESEARCH 

Join a pioneering biotech with a collegial atmosphere and a passion for harnessing every individual’s unique set of skills in our fight against disease.

At Immunocore, we have a vision to transform the way we understand and treat the most challenging medical conditions of our time, including cancer, autoimmune disorders and infection. In January 2022, in the U.S., we launched the world’s first T-cell receptor therapy, built on a novel technology designed to overcome the limitations of our natural immune systems.

Joining us at the most exciting time in our history, you will be part of a team that values trust and innovation, and that cherishes different ways of thinking.

The Role:

To conduct and design experimental investigations, in association with the team and with appropriate guidance from colleagues and managers, enabling the advancement of the Company pipeline, process, or technology capabilities.

Responsibilities:

  • Conducting experiments, observing, interpreting, and responding to results that will support research activities company-wide.
  • Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses.
  • Generate concise reports on-the-fly as data is generated and adapt assays to return most information-rich data.
  • Assimilate multiparameter data and disseminate data in an efficient way.
  • Able to meaningfully contribute to scientific team discussions, with regards to the interpretation of data.
  • Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff.
  • Operating in accordance with the Company’s Health and Safety policies, especially within a laboratory environment.
  • Perform experimental work to contribute to:
    • Development of novel reporter systems/customised cell lines for TCR screening in mammalian cells.
    • Perform genome editing of primary human T cells.
    • Development of in-house target identification approaches to discover/verify novel TCR targets.
  • Experiments: independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others. 
  • Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
  • Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department both internally and externally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge. Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the Company.
  • Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
  • Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment.
  • Health & Safety: championing and helping others to understand H&S within the company, providing ad-hoc training as required.
  • Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.

Qualifications: 

Essential

  • Worked in a bench-based laboratory environment with a recognized and established expertise key techniques relevant to the department.
  • Ability to independently analyse and trouble-shoot the technical aspects of these core techniques.
  • Showing a strong analytical mind with the ability to interpret complex datasets and propose sound experimental strategies.
  • Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change.
  • Driven the direction and progress of work to aid attainment of deadlines or results.
  • Presented detailed scientific findings or papers to internal and external audiences.
  • Ability to network between teams and disciplines.
  • Recorded results in a concise and timely way, and in compliance with agreed standards.
  • Mentored and coached less experienced colleagues in scientific practices and theory.
  • Acted as key point of contact, assuming responsibility for at least one piece of equipment.
  • Expertise in developing novel CRISPR/Cas9-based experimental strategies in mammalian cells.
  • Expertise in multi-parameter flow cytometry and cell sorting.
  • Experience with lentiviral-mediated cell transduction preferably in primary human T-cells.
  • Experience in electroporation-based modification of tumour cell lines and primary human T-cells.
  • Experience of PBMC isolation and primary human T-cell culture and their phenotypic characterisation.
  • Experience in mammalian cell display technology.
  • In depth experience of mammalian cell culture.
  • Proficient in molecular biology techniques: RNA/cDNA/DNA handling, PCR, and in different cloning methods.
  • Proficient in in-silico molecular design and sequence analysis, using bioinformatics tools.
  • Self-motivated, independent, and strong work ethic.
  • Ability to work independently, design and lead research projects, interpret data and troubleshoot, follow and experimental protocols and SOPs.
  • Strong organizational and communication skills.
  • PhD in Cell Biology, Immunology, Cancer Biology, Molecular biology, or related discipline and further experience in biotech/academia (or equivalent).

Desirable

  • Presented posters at external conferences.
  • Led a project small team, formally or informally, through a change in practice including project management.
  • Worked within molecular evolution, immunology or a cancer biology field.
  • Proven publication record.
  • Kept abreast of current scientific writing and concepts.
  • Experience in working with patient tumour samples.
  • Expertise in Next Generation Sequencing (NGS).
  • Experience working with phage and/or yeast display.

Lead with Science and Discover What is Within:

  • We Value Entrepreneurship and Diversity
  • Respect, Trust, and Integrity
  • Competitive compensation
  • Private medical and dental benefits.
  • 25 days Annual Leave and Bank Holidays
  • 4x Salary Life Insurance
  • 5% Pension Match
  • Income Protection
  • Parental Leave

 

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